Mining Company of Sierra Almagrera, and the first seven years of his stay in Almería were the height of his archaeological activities. Here he excavated and researched many sites which helped reveal the two most important cultures of recent prehistory in the Iberian Peninsula: Los Millares and El Argar.
The Museum was initially set up in a building on calle Javier Sanz, and shared the site with the School of Arts and Trades and subsequently with the "Celia Viñas" Secondary School. The name, Luis Siret, was added to the museum's name in tribute to the memory of this distinguished archaeologist.
The collections and the museum were declared a Historical and Artistic Monument in 1962 (Decree no. 474 of 1 March). In 1979, the museum was transferred to the National Ministry of Culture which decided to adapt the former Colegio Menor de Santa María del Mar as the museum's new home, in 1981. It stands in this same square today. The inauguration took place on 22 October 1982. After that, it was called the Museum of Almería although this only became its official title in 1994.
Because of the structural problems due to aluminosis, the building's poor state of conservation led to its closure to the public in 1991, although the museum's internal services continued to function. To reduce the impact of such a prolonged closure as much as possible, two permanent exhibitions were opened in 1995, with a small representative show of Prehistory and Ancient History in Almería outside the museum site, in two places at the Provincial Historical Archive and the Villaespesa Library. At a later date, a single exhibition was organised in the Villaespesa Library called "Archaeological Testimonies in the province of Almería".
The Ministry of Culture decided to erect a new building on the same plot following the demolition of the old site. In the meantime, the inside areas were moved to buildings belonging to the Provincial Council, in the former Colegio Virgen del Pilar. Some of the storerooms were also moved there. The remaining items in storage were moved to the former Psychiatric Hospital.
Architects Ángela García Paredes and Ignacio García Pedrosa were responsible for designing the new museum site. The result is a building in contemporary style. Its architectural design is primarily intended to provide a strategic makeover of the museum's location. The block, where it used to be, has been reorganised following the creation of a large public square that looks over the city, with an extensive gardened area intended as an area for relaxation. Inside, the spaces are impressively arranged to combine light, contrasting heights and aesthetics in attractive woodwork. The central space of the hall and double stairs give structure to the approach adopted in the architecture and museography, helping visitors to move freely on various themed tours. The building was awarded the PAD and ARCO 2004 prizes and was a finalist in the FAD awards in 2005.
On 23 March 2006 the Prince and Princess of Asturias inaugurated the new site and opened the Museum of Almería to the public.